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CAPRINE ARTHRITIS/ENCEPHALITIS - PHILIPPINES: COMPARATIVE MEDICINE ASPECTS - ProMED Post - Tuesday, September 21, 2010

CAPRINE ARTHRITIS/ENCEPHALITIS - PHILIPPINES: COMPARATIVE MEDICINE ASPECTS

 

Please see a notable One Health ProMED-mail posting on One Health Initiative Website ProMED Page - Tuesday, September 21, 2010.
 http://www.onehealthinitiative.com/promed.php
http://www.promedmail.org/pls/apex/f?p=2400:1001:4788988141084359::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,84924 

 


One Health Advocate/Supporter Website Promotes Global Cancer Awareness - Monday, September 20, 2010

One Health Advocate/Supporter Website Promotes Global Cancer Awareness

 

A recent global call to action is now promoted on the “Millennium Medicine Project Global Cancer Initiative” of the Humanitarian Resource Institute.  This website’s One Health advocacy http://www.humanitarian.net/biodefense/fazdc/zdc1/ was previously reported on a One Health Initiative website News item April 24, 2010 (scroll down). 

While scrolling down, please note the specific One Health Cancer News items highlighted, e.g. the first item under this announcement: “One Health in ACTION: Human Breast Cancer Comparative Medicine Research Advances at MD Anderson Cancer Center”. 

Two of many cancer references of interest:

1.       Head and Neck Program at Smilow Cancer Hospital and the Yale School of Medicine. http://www.yaleheadandneck.org/

2.       Cancer - Key Facts: World Health Organization. http://www.who.int/mediacentre/factsheets/fs297/en/index.html


One Health in ACTION: Human Breast Cancer Comparative Medicine Research Advances at MD Anderson Cancer Center - Friday, September 17, 2010

One Health in ACTION: Human Breast Cancer Comparative Medicine Research Advances at MD Anderson Cancer Center

 

Physicians, PhDs, and Veterinarians working collaboratively and synergistically

 

Department of Veterinary Sciences, Michale E. Keeling Center for Comparative Medicine and Research, The University of Texas

 

 Provided September 13, 2010 by:

 

Christian R. Abee, DVM, MS, DACLAM
Doctor R. Lee Clark Professor and Chair
Department of Veterinary Sciences
Director, Michale E. Keeling Center for Comparative Medicine and Research
University of Texas MD Anderson Cancer Center
Bastrop, TX 78602

Email:  cabee@mdanderson.org
Telephone: (512) 321-3991

 

Research at the Keeling Center has led to discovery of new breast cancer therapeutic monoclonal antibodies, and the development of early breast cancer tests based on the antibodies.  These antibodies were discovered in the laboratory of Keeling Center investigator Dr. Feng Wang-Johanning [MD, PhD] and her Keeling Center collaborator, Dr. Gary Johanning [PhD].  The monoclonal antibodies are directed against an ancient retrovirus that originated outside the human body as a remnant of an exogenous retrovirus, and subsequently became incorporated into the genome of primates millions of years ago.  This retrovirus, termed human endogenous retrovirus (HERV), currently resides in the genome of all humans. 

 

Dr. Wang-Johanning and Dr. Johanning are focusing their studies on one highly active subgroup of HERV, HERV type K.  HERV-K is not usually expressed in normal, non-cancer cells, but they found that its expression re-emerges in human breast cancer, making it a good target for antibody therapy.  Dr. Wang-Johanning’s major research discovery to date is that monoclonal and single chain antibodies against HERV-K are effective in inhibiting breast cancer cell proliferation and inducing cell cycle arrest and apoptosis, both in vitro and in vivo.  Pivotal studies in immunodeficient mice demonstrated that tumor sizes were significantly reduced, and onset of tumorigenesis was significantly delayed, in antibody-treated mice bearing breast tumors. 

 

HERV-K is thus a novel antigen target for breast cancer, and Dr. Wang-Johanning’s pre-clinical studies provide compelling evidence that antibodies to HERV-K have the potential to be effective therapeutic agents for treating breast cancer.  She is currently developing humanized and human antibodies for clinical trials, aimed at translating her laboratory results to breast cancer patients.  Drs. Wang-Johanning and Johanning are hopeful that this antibody will rival the effectiveness of the well-known breast cancer therapeutic antibody Herceptin.  There is reason for their optimism, because while Herceptin is effective against only 25-30 percent of breast cancers, anti-HERV-K antibodies have the potential to be effective against almost all human breast cancers. 

 

The research of Dr. Wang-Johanning and collaborators has just taken an exciting turn.  They are taking advantage of the presence of HERV-K in breast cancer to develop early breast cancer tests.  These tests are based on detection of anti-HERV-K serum antibodies and viral RNA, and will be analogous to the PSA test that is widely used for prostate cancer screening.  There is a need for these tests, because currently there are no sensitive and specific serum tests for breast cancer.

 

These discoveries would not have been possible without “One Health” collaboration between Dr. Wang-Johanning’s group and investigators at the main M. D. Anderson Cancer Center campus in Houston.  Kelly Hunt, MD, breast cancer surgeon, provided breast cancer serum and tumor tissues for Dr. Wang-Johanning’s projects.  In addition, Stephan Ambs, PhD, National Cancer Institute, is collaborating with Dr. Wang-Johanning’s laboratory to assess the clinical significance of elevated HERV-K in breast cancer.  Bruce Bernacky, DVM at the Keeling Center, will also play a prominent role in upcoming studies with Dr. Wang-Johanning because he will provide access to primates for testing her antibodies prior to human clinical trials. 

________________________________________________

 

Note: Please see the current issue of the Institute of Laboratory Animal Research (ILAR) Journal which contains “One Health: The Intersection of Humans, Animals and the Environment – Scientific Editor: James G. Fox, DVM, MS [2010 Volume 51, Number 3]

http://dels-old.nas.edu/ilar_n/ilarjournal/51_3/html/

 

ILAR Journal and ILAR e-Journal
The National Academies
500 Fifth Street, NW
Washington, DC 20001
202-334-2590

202-334-1687 fax
ILARJ@nas.edu

Cameron Fletcher
, Managing Editor cfletcher@nas.edu


A One Health Challenge - An Innovative Approach to Graduate Public Health Education - Tuesday, September 14, 2010

A One Health Challenge

An Innovative Approach to Graduate Public Health Education

The Master of Public Health (MPH) Program at Kansas State University in Manhattan, Kansas (USA) is not what one would normally expect from graduate public health education.  While a few other Master of Public Health programs in the United States are aligned with a College of Veterinary Medicine, K-State’s program is housed in one.  And, four other colleges on the campus are partners to make it truly interdisciplinary. 

Started in the fall semester of 2003, the Kansas State MPH Program was initiated as a collaboration of the Graduate School and the Colleges of Agriculture, Arts & Sciences, Human Ecology, and Veterinary Medicine, with the first interim director from Human Ecology.  This innovative approach was both cost effective and efficient with its use of existing infrastructure, faculty and courses.  Today, the college partners are still the same, and the program has its first full-time Director, Mike Cates, DVM, MPH, also a Professor in the College of Veterinary Medicine.  Dr. Cates is the former Chief of the Army Veterinary Corps and the first veterinarian to serve as the Commanding General of the Army’s main public health organization, the Center for Health Promotion and Preventive Medicine as well as the Surgeon General’s primary senior executive on Preventive Medicine and Public Health. 

The partnership, crossing traditional college boundaries at Kansas State University, has a definite advantage for students.   There are over 55 different faculty members affiliated with the MPH Program, from 8 departments in the 4 participating academic colleges.  This variety of disciplines and research interests opens a wealth of possibilities for students, who, despite the newness of the program and the relatively small size, can choose between four distinct areas of emphasis—Infectious Diseases and Zoonoses; Food Safety and Biosecurity; Public Health Nutrition; and Public Health Physical Activity.  Dr. Cates noted “The faculty members here are extraordinary experts in many different areas which impact on animal, human and/or environmental health.  You will probably not find such a unique blend anywhere else.”

That uniqueness and breadth has led to significant growth in enrollment.  When Dr. Cates arrived in January 2009, the program had an enrollment of 26 students; today, there are 75.  One noticeable trait of the program is the high interest level of veterinarians, veterinary students and even pre-professional students to pursue the MPH degree or the Graduate Certificate in Public Health Core Concepts.  Right now, over half of the MPH students fit into one of those veterinary-related categories.  Overall, the program has attracted outstanding domestic and international students from over 15 disciplines, including medicine, nursing, dentistry, human nutrition, kinesiology, animal science, food science and several others, from 17 states and 11 different countries.

The future looks bright for even more opportunities for students and graduates of this program, with the arrival of two major federal laboratories—the National Bio and Agro-Defense Facility and the Arthropod Borne Animal Disease Research Unit—a continuing and growing culture of teamwork across the state.  The program is exploring ways to collaborate with the University of Kansas’ more traditional program, and the two universities already play active roles in the state’s Public Health Systems Group, involving local and state governmental agencies along with foundations and other health-related stakeholders, and the Public Health Workforce Development Group.  In another example, Kansas State MPH faculty and students help in public health outreach, education and research with the university’s One Health Kansas and Pathways to Public Health initiatives, aiming to raise awareness and interest in public health, starting with children in kindergarten, and ultimately to improve the numbers and quality of educated professionals in the public health workforce. 

A crucial component of the tremendous growth of the K-State MPH Program is the interest, advocacy and support from the university’s administrative leadership, particularly the college deans and the past and present university provosts and presidents.  “Without the consistent and adequate support of the university and the college leaders, such an innovative interdisciplinary approach to education would not succeed,” Dr. Cates noted.  “We are very fortunate here to have visionaries who are willing to fund non-traditional approaches in a field where multidisciplinary methods really make the most sense. Prevention is the best way to health, and collaboration is key.  Together, we must set a ‘one health’ example among all stakeholders, for improved community health throughout our state and beyond.” 



Dr. Carol Ann Holcomb, first Interim Director of MPH Program, receiving Excellence in Public Health Award from Dr. Mike Cates.


Mike Cates, DVM, MPH, current Director, MPH Program


New MPH and Public Health Graduate Certificate Students for Fall 2010


Picture from campus


One Health Poster Representation at Farm Foundation Symposium by Two Department of Homeland Security Centers of Excellence - Thursday, September 09, 2010

One Health Poster Representation at Farm Foundation Symposium by Two Department of Homeland Security Centers of Excellence

 

Titled: “One Health – One Medicine – One Environment”

 

Two outstanding Department of Homeland Security Centers of Excellence—the Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), Kansas State University and National Center for Foreign Animal and Zoonotic Disease Defense (FAZD), Texas A & M University, will jointly present One Health posters at the Farm Foundation Symposium in Washington,  D.C. on September 23rd and 24th, 2010.  They will be titled “One Health-One Medicine-One Environment” to help reflect the interdisciplinary, all inclusive approach offered by One Health principles for health and health care problem solving.

 

The two-day interdisciplinary symposium’s topic is “Zoonoses: Understanding the Animal Agriculture and Human Health Connection.” The program is targeted at a broad cross-section of people, including public health officials, veterinarians, physicians, virologists, agricultural producers, public policy makers and media representatives. For the conference program and registration details see: www.farmfoundation.org. 

 

Both FAZD Center (http://fazd.tamu.edu), headquartered at Texas A&M University, and CEEZAD (http://sites.google.com/site/ceezad/home), headquartered at Kansas State University, seek to perform research and develop products that will defend the nation against high-consequence foreign animal and emerging/zoonotic diseases. Since at least 60 percent of all human pathogens originate in animals, the link between human medicine, veterinary medicine and our ecosystem is crucial for human health. There is also increasing awareness that in order to meet the One Health goal of uniting human and veterinary medicine, the impact of the environment is very important.  Therefore, both Centers will develop a theme of “One Health-One Medicine-One Environment” in their Conference poster displays.

 

For further information please contact: Karinne Cortes at CEEZAD: email address

Kcortes@vet.k-state.edu  telephone: 1-785-532-4614   or Lori Olivarez at FAZD: email address lrolivarez@ag.tamu.edu; telephone: 1-979-845-2855.

 

Note: The One Health Initiative website team strongly supports and applauds this collaborative approach for promoting the One Health concept.

 


Two Important One Health Tuberculosis Articles – Published by “The International Journal of Tuberculosis and Lung Disease” - Wednesday, September 08, 2010

Two Important One Health Tuberculosis Articles – Published by “The International Journal of Tuberculosis and Lung Disease

The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

Thoen C O, LoBue P A, de Kantor I. Why has zoonotic tuberculosis not received much attention? [Editorial]

 

 http://www.ingentaconnect.com/content/iuatld/ijtld/2010/00000014/00000009/art00001 or directly to the pdf:

 

 http://docstore.ingenta.com/cgi-bin/ds_deliver/1/u/d/ISIS/58527281.1/iuatld/ijtld/2010/00000014/00000009/art00001/7086BA00A165E4C012839704191CCE7B19C34A6FF6.pdf?link=http://www.ingentaconnect.com/error/delivery&format=pdf                  

 

LoBue P A, Enarson D A, Thoen CO. Tuberculosis in humans and animals: an overview [Serialised article. Tuberculosis: a re-emerging disease in animals and humans. Number 1 in the series]

 

 http://www.ingentaconnect.com/content/iuatld/ijtld/2010/00000014/00000009/art00002 or directly to the pdf

 

http://docstore.ingenta.com/cgi-bin/ds_deliver/1/u/d/ISIS/58527321.1/iuatld/ijtld/2010/00000014/00000009/art00002/3B8E9C47DB8EA15012839705518C2A9210DED7F128.pdf?link=http://www.ingentaconnect.com/error/delivery&format=pdf

 

Website posting approval granted:  September 8, 2010


American Medical Association (USA) President Reaffirms Strong Support of One Health - Monday, August 30, 2010

American Medical Association (USA) President Reaffirms Strong Support of One Health

 

 

"The AMA strongly supports the One Health Initiative, the collaborative effort of multiple disciplines to attain optimal health for humans, animals, and our environment. More than 60 percent of human infectious diseases and the preponderance of emerging infectious diseases have an animal vector. Better collaboration is needed between human and veterinary medicine to protect the public health. The One Health Initiative is playing an important role in achieving this goal."

 

Cecil B. Wilson, MD, President,

American Medical Association

 

Message for posting on the One Health Initiative website received August 30, 2010


A second good reason to attend the … “One Health” Session Scheduled for the North American Veterinary Conference (NAVC), in Orlando, Florida (USA) Monday, January 17, 2011 - Thursday, August 26, 2010

A second good reason to attend the …

“One Health” Session Scheduled for the North American Veterinary Conference (NAVC), in Orlando, Florida (USA) Monday, January 17,  2011 www.navc.com

Remember the first good reason to attend was described about and by Dr. Paul P. Calle.   It was posted on August 13, 2011 (scroll down).

Here is a second outstanding featured speaker, an activist wildlife veterinarian:

 

Kirsten Gilardi, DVM, DACZM

Assistant Director, UC Davis Wildlife Health Center
School of Veterinary Medicine
University of California, Davis, CA (USA)
One Shields Avenue
Davis, CA 95616-8739
E-mail: kvgilardi@ucdavis.edu

 

Dr. Gilardi says she has directed her veterinary career towards One Health efforts, “whether that be providing clinical care to wildlife species endangered due to human-related activities, researching the health status of wildlife species as indicators of the health of their ecosystems, directing the One Health-focused Envirovet Summer Institute, or now administering the Mountain Gorilla One Health Program.  As a wildlife veterinarian, a One Health framework for my endeavors is the most effective and only meaningful approach.”  Dr. Gilardi said, “it is highly rewarding on a professional and personal level.”

Speech topic: “One Health in ACTION” - DETECTING WILDLIFE ZOONOSES TO PREVENT HUMAN PANDEMICS 

Dr. Gilardi describes her excellent and illuminating One Health message:

 The United States Agency for International Development (USAID) Emerging Pandemic Threats Program (EPT) is a recently launched international effort to detect emerging wildlife zoonoses in time to prevent human pandemics. The EPT is an excellent example of One Health in Action; in particular, its PREDICT project http://www.vetmed.ucdavis.edu/ohi/predict/index.cfm, is administered by the UC Davis Wildlife Health Center in partnership with Wildlife Conservation Society, Wildlife Trust, Global Viral Forecasting, Inc. and the Smithsonian Institution.  It is working on the ground on the One Health frontline, conducting wildlife zoonoses and emerging disease surveillance in more than two dozen countries at high-risk wildlife-human interfaces such as bushmeat hunting and wildlife ecotourism.”

In coming months, the One Health Initiative website will feature other topics to be discussed by individual speakers in the NAVC scheduled Orlando, Florida (USA) One Health session. 

 

Private practicing veterinarians, physicians and other health scientists in the U.S., Canada and worldwide are urged to consider attending.  These issues are expected to impact each of you as the One Health movement continues to exponentially expand globally.

 

 


Dr. Dunham Supports AVMA/AMA “One Health” Initiative - Monday, August 16, 2010

U.S. Food and Drug Administration’s (FDA) Bernadette Dunham, DVM, PhD Supports AVMA/AMA “One Health” Initiative

FDA Veterinarian Newsletter 2007 Volume XXII, No IV - Dr. Dunham Supports AVMA/AMA “One Health” Initiative

http://www.fda.gov/AnimalVeterinary/NewsEvents/FDAVeterinarianNewsletter/ucm109489.htm

-         Last Updated Version below: 10/28/2009

Dr. Bernadette Dunham, [Current] Director of the FDA’s Center for Veterinary Medicine (USA), is a strong proponent of the initiative called “One Health,” aimed at developing more collaboration and communication between human and veterinary medicine. 

The concept behind the One Health initiative is not new (it was first articulated in the 19th Century), but it gained increased attention as the American Medical Association’s House of Delegates voted in June to approve a resolution to support it, and the American Veterinary Medical Association (AVMA) in July at its annual convention named members to a One Health Initiative Task Force. AVMA had endorsed the concept earlier.

Dr. Roger Mahr, Immediate Past President of the AVMA, made the One Health initiative his top priority during his presidency (2006-2007). It was his recommendation to establish the task force.

According to an AVMA press release, the task force was given the job of “articulating a vision of One Health that will enhance the integration of animal, human, and environmental health for the mutual benefit of all.”

The One Health initiative addresses the significance of zoonotic diseases. The most obvious zoonotic diseases are variant Creutzfeldt-Jakob disease, West Nile virus, avian influenza, rabies, and salmonellosis. But many other diseases can move between humans and animals. Approximately 60 percent of all infectious agents of humans are zoonotic, according to experts. In addition, 75 percent of emerging human diseases seen in the past 25 years have been zoonotic, AVMA’s Dr. Mahr stated during the group’s annual conference in July.

The leading advocates of the initiative are Dr. Laura H. Kahn, a physician on the research staff of the Woodrow Wilson School of Public and International Affairs, Princeton University; Dr. Bruce Kaplan, a veterinarian in Sarasota, FL, and previously with the [U.S. Centers for Disease Control & Prevention and] U.S. Department of Agriculture’s Food Safety and Inspection Service; and Dr. Thomas P. Monath, a physician previously with the Centers for Disease Control and Prevention (Fort Collins, CO) and the U.S. Army Medical Research Institute of Infectious Diseases (Fort Detrick, MD), and currently with the investment firm Kleiner Perkins Caufield & Byers, Menlo Park, CA.

They have drafted this One Health mission statement:

“Recognizing that human and animal health are inextricably linked, One Health seeks to promote, improve, and defend the health and well-being of all species by enhancing cooperation and collaboration between physicians and veterinarians, and by promoting strengths in leadership and management to achieve these goals.”

The initiative seeks increased educational opportunities between human and veterinary medical schools, more communications, and more cross-species disease surveillance, as well as other coordination.

Dr. Kaplan is collecting statements of support for the One Health initiative. Dr. Dunham, who has had veterinary clinical experience as well as human and veterinary research experience, sent him this statement of support:

“Sir William Osler, M.D. (1849-1919) promoted the philosophy of ‘one medicine.’ How exciting to witness, in 2007, the official adoption of the ‘One Health’ initiative by both the AMA and the AVMA!! Through mutual collaborations—clinical and research experiences—veterinarians and physicians can accomplish so much more together to advance the health of humans and animals. Today, we truly live in a global village where people, animals, and microbes all travel. So, it is even more imperative that we all embrace the One Health initiative. I look forward to joining my colleagues in a multidisciplinary approach as we address the global health needs of humans, animals, and their environment.”

Others who have sent testimonials supporting the One Health Initiative include Major General Gale S. Pollock, Acting, Surgeon General, U.S. Army; and former U.S. Senator Bill Frist, MD.  Dr. Kaplan is continuing to collect testimonials. [please see http://www.onehealthinitiative.com/endorsements.php]

                                                   *     *     *     *       

Note: Jack Woodall, PhD, a renowned viral epidemiologist, became the contents manager/editor of the ProMED-mail section in the Kahn-Kaplan-Monath-Woodall One Health Initiative website http://www.onehealthinitiative.com in February 2009.  Dr. Woodall is visiting Professor and Director (retd.) Nucleus for the Investigation of Emerging Infectious Diseases at the Institute of Medical Biochemistry, Center for Health Sciences, Federal University of Rio de Janeiro, Brazil.  He is a co-founder and associate editor of ProMED-mail, the outbreak early warning system online of the Program for Monitoring Emerging Diseases of the International Society for Infectious Diseases.


“One Health” Session Scheduled for the North American Veterinary Conference (NAVC), in Orlando, Florida (USA) Monday, January 17, 2011 - Friday, August 13, 2010

A good reason to attend the …

“One Health” Session Scheduled for the North American Veterinary Conference (NAVC), in Orlando, Florida (USA) Monday, January 17,  2011 www.navc.com

One of the outstanding featured speakers, a noted wildlife veterinarian will be:

 

Paul P. Calle, VMD, Dipl ACZM
Director, Zoological Health

Global Health Program

Wildlife Conservation Society

2300 Southern Blvd.

Bronx, NY 10460-1099

www.wcs.org

 

Dr. Calle’s speech will explore ““One World One Health®  – A Field Veterinary Perspective”.

 

Dr. Calle cogently and briefly describes his One Health message as “The inextricable link between people, domestic and wild animals, and their diseases, has never been more obvious or of concern than it is today. With outbreaks of SARS, Highly Pathogenic Avian Influenza, and Ebola virus capturing the public’s attention, the concept that we only have One World and share One Health is on the front pages of newspapers around the world. The need to increase the linkages between public health, the health of domestic animals, and the health and conservation of wild animals has generated discussions and collaborations unheard of only a few years ago. This talk will present an overview of the Wildlife Conservation Society’s pioneering One World One Health® activities around the world, which include international symposia and workshops on the topic held in New York City and Bangkok, Thailand in 2004; Beijing, China in 2005; and Brasilia, Brazil in 2007 as well as ongoing global field veterinary activities to investigate diseases and their relationships to people, domestic and wild animals.”

 

In coming months, the One Health Initiative website will feature other topics to be discussed by individual speakers in the NAVC scheduled One Health session. 

 

Private practicing veterinarians, physicians and other health scientists in the U.S., Canada and worldwide are urged to consider attending. 

 

 

 

 


 
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