One Health Publications

“...To the best of our knowledge, this is the first report to provide a comprehensive expression analysis of the most important CAS markers in canine simple mammary carcinomas and further supports the validity of the dog as model for human cancer. ...”

Int. J. Mol. Sci. 2017, 18(5), 1101; doi:10.3390/ijms18051101

Analysis of Gene Expression Signatures in Cancer-Associated Stroma from Canine Mammary Tumours Reveals Molecular Homology to Human Breast Carcinomas

Julia Ettlin ¹

, Elena Clementi ¹

, Parisa Amini ¹

, Alexandra Malbon ²

and Enni Markkanen ^1,*

¹

Institute of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Zürich, Winterthurerstr. 260, 8057 Zürich, Switzerland

²

Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Winterthurerstr. 268, 8057 Zürich, Switzerland

^*

Author to whom correspondence should be addressed.

Academic Editor: Sanjay K. Srivastava

Received: 14 February 2017 / Revised: 3 May 2017 / Accepted: 17 May 2017 / Published: 20 May 2017

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

View Full-Text   |   Download PDF [6438 KB, uploaded 20 May 2017]   |  

See: http://www.mdpi.com/1422-0067/18/5/1101

Cancer-associated stroma (CAS) plays a key role in cancer initiation and progression. Spontaneously occurring canine mammary carcinomas are viewed as excellent models of human breast carcinomas. Considering the importance of CAS for human cancer, it likely plays a central role in canine tumours as well. So far, however, canine CAS lacks characterisation, and it remains unclear whether the biology between CAS from canine and human tumours is comparable. In this proof-of-principle study, using laser-capture microdissection, we isolated CAS and normal stroma from 13 formalin-fixed paraffin embedded canine simple mammary carcinomas and analysed the expression of seven known human CAS markers by RT-qPCR (Reverse Transcription quantitative PCR) and validated some targets by immunohistochemistry. We found that Col1a1 (Collagen1α1), αSMA (alpha Smooth Muscle Actin), FAP (Fibroblast activation protein), PDGFRβ (Platelet-derived growth factor receptor beta), and Caveolin-1 were significantly upregulated in canine CAS, and the expression of CXCL12 (Stromal cell derived factor 1) significantly decreased, whereas MMP2 (Matrix Metalloproteinase 1) and IL6 (Interleukin 6) did not change. Our results suggest strong similarities in CAS biology in canine and human mammary carcinomas but also reveal some differences. To the best of our knowledge, this is the first report to provide a comprehensive expression analysis of the most important CAS markers in canine simple mammary carcinomas and further supports the validity of the dog as model for human cancer. View Full-Text

THE ROYAL SOCIETY

“Theme issue ‘One Health for a changing world: zoonoses, ecosystems and human well-being’ compiled and edited by Andrew Cunningham, Ian Scoones and James Wood”

19 July 2017; volume 372, issue 1725 http://rstb.royalsocietypublishing.org/content/372/1725

CAB Reviews

A reviews journal covering agriculture, global health, nutrition, natural resources and veterinary science

Open Access

Roadmap to a One Health agenda 2030

View full text article

Abstract

“The current fragmented framework of health governance for humans, animals and environment, together with the conventional linear approach to solving current health problems, is failing to meet today's health challenges and is proving unsustainable. Advances in healthcare depend increasingly on intensive interventions, technological developments and expensive pharmaceuticals. The disconnect grows between human health, animal health and environmental and ecosystems health. Human development gains have come with often unrecognized negative externalities affecting ecosystems. Deterioration in biodiversity and ecosystem services threatens to reverse the health gains of the last century. A paradigm shift is urgently required to de-sectoralize human, animal, plant and ecosystem health and to take a more integrated approach to health, One Health (OH). The Sustainable Development Goals (SDGs) offer a framework and unique opportunity for this. Through analysing individual SDGs, we argue the feasibility of an OH approach towards achieving them. Feasibility assessments and outcome evaluations are often constrained by sectoral politics within a national framework, historic possession of expertise, as well as tried and tested metrics. OH calls for a better understanding, acceptance and use of a broader and transdisciplinary set of assessment metrics. Key objectives of OH are presented: that humans reconnect with our natural past and accept our place in, and dependence on our planet's ecosystems; and that we recognize our dependence on ecosystem services, the impact of our development thereon and accept our responsibility towards future generations to address this. Several action points are proposed to meet these objectives.”

View full text PDF article http://www.cabi.org/cabreviews/FullTextPDF/2017/20173134856.pdf

  or

http://www.cabi.org/cabreviews/review/20173134856

The Principles and Practice of Q Fever: The One Health Paradigm

Nova Science Publishers

A significant amount of comprehensive information based on the One Health approach is shared with the readers. We expect that the contents of this ...

Development of a project proposal supporting a sustainable future for people and planet

http://africahealthnews.com/development-project-proposal-supporting-sustainable-future-people-planet/

Volume 3, June 2017, Pages 56–65

http://www.sciencedirect.com/science/article/pii/S2352771416300830

Open Access

One Health in food safety and security education: Subject matter outline for a curricular framework

• John A. Angelos^, ,

• Amanda L. Arens,

• Heather A. Johnson,

• Jessica L. Cadriel,

• Bennie I. Osburn

• Western Institute for Food Safety and Security, University of California – Davis, 1477 Drew Ave., Suite 101, Davis, CA 95618, United States

  Abstract

  “Educating students in the range of subjects encompassing food safety and security as approached from a One Health perspective requires consideration of a variety of different disciplines and the interrelationships among disciplines. The Western Institute for Food Safety and Security developed a subject matter outline to accompany a previously published One Health in food safety and security curricular framework. The subject matter covered in this outline encompasses a variety of topics and disciplines related to food safety and security including effects of food production on the environment. This subject matter outline should help guide curriculum development and education in One Health in food safety and security and provides useful information for educators, researchers, students, and public policy-makers facing the inherent challenges of maintaining and/or developing safe and secure food supplies without destroying Earth's natural resources.”

   

http://www.healthforanimals.org/animalhealthmatters/

ALSO SEE: https://www.agra-net.com/agra/animal-pharm/business/markets/new-platform-puts-spotlight-on-animal-global-health-552769.htm

American Association of Public Health Physicians (AAPHP)

Supports the “One Health” concept & approach

SEE: http://www.aaphp.org/OneHealth

http://www.downtoearth.org.in/news/health-ministers-commit-to-address-antimicrobial-resistance-in-g20-summit-57914