A significant One Health translational medicine research approach…Regrowth of injured muscles in mice and humans has been demonstrated by a multidisciplinary research team.   “An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss”   Citation: B. M. Sicari, J. P. Rubin, C. L. Dearth, M. T. Wolf, F. Ambrosio, M. Boninger, N. J. Turner, D. J. Weber, T. W. Simpson, A. Wyse, E. H. Brown, J. L. Dziki, L. E. Fisher, S. Brown, S. F. Badylak, An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss. Sci. Transl. Med. 6, 234ra58 (2014). Abstract “Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients. …” Please read abstract and/or entire article at: Reprint: Full Text:   A method for regenerating large amounts of muscle loss after injury using material from pig bladders has been developed by a multidisciplinary research team from the University of Pittsburgh, led by Stephen F. Badylak, DVM, PhD, MD, University of Pittsburgh Research Professor, Department of Surgery, Director of Tissue Engineering, McGowan Institute of Regenerative Medicine.  Dr. Badylak has a veterinary medical and human medical educational background and is a longstanding supporter of the One Health concept   Open access link with Expiration Date = 30 Jun 2014 graciously provided to the One Health Initiative website by:  “This article is available for reading with full access through June 30, 2014 via referrer link, no fee, [on the One Health Initiative website].  The link will provide seamless access for the period mentioned and then revert to a regular hyperlink after that.  After that readers may use pay-per-view if they do not subscribe.  This paper becomes free with registration after 1 year from it’s publication, as does all our research content.” (Ms.) Elizabeth Sandler Rights & Permissions Science/AAAS 1200 New York Ave. NW Washington, DC 20005 Tel: + 1-202-326-6765