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Breast cancer drug Supinoxin shows potential for small-cell lung cancer in new tests

Purdue University scientists have identified the Supinoxin small-molecule drug as a possible new therapy for small-cell lung cancer. Elizabeth Tran, professor of biochemistry in the College of Agriculture, and co-principal investigator Bennett Elzey, associate research professor of comparative pathobiology in the College of Veterinary Medicine, have published their results in the journal iScience. The team suggests that Supinoxin will more effectively treat tumors when combined with another therapeutic. The latest experiments probed the effects of Supinoxin on DDX5 protein activity in cancerous human cell lines and in an animal model.

Media contact: Erin Murphy, ermurphy@purdue.edu