GUIDING PRINCIPLE 9. Negotiate an effective legally binding pandemic agreement with a One Health approach and strengthened International Health Regulations. This fills the gaps in the international rulebook for pandemic preparedness and response, requiring countries and empowering the WHO to report and investigate pandemic threats rapidly. The pandemic agreement should include concrete provisions on anti-microbial resistance.

GUIDING PRINCIPLE 11. Apply a comprehensive One Health approach and intensify the fight against antimicrobial resistance. Two critical challenges have become more urgent in recent years. The first concerns the complexity and the consequences of animal, environmental and human interactions calling for a multisectoral, integrated and transdisciplinary “One Health” approach.