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Commentary Altered metabolism in cancer Jason W Locasale1,2 and Lewis C Cantley1,2 1  Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA 2  Beth Israel Deaconess Medical Center, Department of Medicine, Division of Signal Transduction, Boston, MA 02215, USA author email corresponding author email BMC Biology 2010, 8:88 doi:10.1186/1741-7007-8-88 Published: 25 June 2010 http://www.biomedcentral.com/1741-7007/8/88   © 2010 Locasale and Cantley; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.