Commentary Altered metabolism in cancer Jason W Locasale1,2 and Lewis C Cantley1,2 1  Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA 2  Beth Israel Deaconess Medical Center, Department of Medicine, Division of Signal Transduction, Boston, MA 02215, USA author email corresponding author email BMC Biology 2010, 8:88 doi:10.1186/1741-7007-8-88 Published: 25 June 2010   © 2010 Locasale and Cantley; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.