An important biomedical research project... an ideal One Health project Open Access – PLOS bIOLOGY Unsolved Mysteries discuss a topic of biological importance that is poorly understood and in need of research attention. * E-mail: firstname.lastname@example.org Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America ⨯ Why Is Aging Conserved and What Can We Do about It? http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002131 Jason N. Pitt, PhD, Matt Kaeberlein, PhD Published: April 29, 2015 DOI: 10.1371/journal.pbio.1002131 Pitt JN, Kaeberlein M (2015) Why Is Aging Conserved and What Can We Do about It? PLoS Biol 13(4): e1002131. doi:10.1371/journal.pbio.1002131 Abstract “The field of aging research has progressed rapidly over the past few decades. Genetic modulators of aging rate that are conserved over a broad evolutionary distance have now been identified. Several physiological and environmental interventions have also been shown to influence the rate of aging in organisms ranging from yeast to mammals. Here we briefly review these conserved pathways and interventions and highlight some key unsolved challenges that remain. Although the molecular mechanisms by which these modifiers of aging act are only partially understood, interventions to slow aging are nearing clinical application, and it is likely that we will begin to reap the benefits of aging research prior to solving all of the mysteries that the biology of aging has to offer.” Drs. Pitt http://kaeberleinlab.org/people/jason-pitt and Kaeberlein http://www.pathology.washington.edu/faculty/kaeberlein are affiliated with the Department of Pathology, University of Washington, Seattle, WA (USA).
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