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In the United States, One Health—the collaborative approach recognizing the interconnectedness of human, animal, and environmental health—is primarily promoted by a network of federal agencies, professional associations, and non-profit organizations.

Key Federal Agencies

The U.S. government formalizes coordination through the U.S. One Health Coordination Unit (U.S. OHCU), launched in January 2024 to lead the National One Health Framework.

 

• Centers for Disease Control and Prevention (CDC): The CDC One Health Office, established in 2009, is the lead for domestic and global activities, focusing on zoonotic diseases, outbreak response, and the Healthy Pets, Healthy People program.
• U.S. Department of Agriculture (USDA): Focuses on domestic animal health, food safety, and antimicrobial resistance through its Animal and Plant Health Inspection Service (APHIS).
• Department of the Interior (DOI): Manages wildlife and environmental health, collaborating with the U.S. Geological Survey (USGS) and the Fish and Wildlife Service to monitor diseases in wild populations.
• Food and Drug Administration (FDA): Through its Center for Veterinary Medicine (CVM), the FDA applies One Health to drug safety and antimicrobial stewardship.

 

Professional Associations & Non-Profits

These organizations were instrumental in the movement's early growth and continue to lobby for One Health legislation.

• American Veterinary Medical Association (AVMA): A primary champion of One Health legislation; it collaborated with the AMA in 2007 to pass resolutions promoting the approach.
• American Medical Association (AMA): Partnered with the AVMA to bridge human and veterinary medicine.
• One Health Commission: A major non-profit that maintains a global "Who's Who" directory and facilitates educational and social science initiatives.
• One Health Initiative Autonomous Team: A pro-bono group that manages a widely used informational clearinghouse to promote "One Medicine".
• EcoHealth Alliance: A science-based non-profit focused on research and outreach at the interface of wildlife, ecosystems, and human health.
• National Environmental Health Association (NEHA): Promotes the environmental health pillar of the One Health triad.

 

Academic & Research Leaders

Many U.S. universities host centers dedicated to One Health research and training.

• One Health Trust (OHT): Conducts state-of-the-art research on antimicrobial resistance and infectious disease modeling from its Washington, D.C. office.
• University Centers: Prominent programs exist at Colorado State University (One Health Institute), The Ohio State University (Global One Health initiative), and the University of Washington (One Health Clinic).