One Health Publications

Abstract

One Health is a concept and framework for addressing the interconnected nature of humans, animals and their environments to improve the health and wellbeing of all three, along with added social and financial benefits. On a microscopic level, the microbiota is a clear biological connector with strains shared across domains (One Health Microbiome). In this review, we introduce the concept of One Health and the One Health Microbiome and discuss strain-sharing across and within domains. We also highlight its impact on the spread of antimicrobial resistance (AMR) genes as well as overall microbiome diversity and resilience to climate change. Finally, we discuss critical areas for further research and conceptual development, encouraging future research integrating One Health and microbiota-AMR concepts.

Highlights

• Environmental, animal and human microbiomes are connected, forming together the so-called “One Health Microbiome”.
• Within the One Health Microbiome, there is extensive sharing of strains, contributing to positive outcomes, such as buffering against stressors like climate change, and negative outcomes, such as sharing of pathogens and antimicrobial resistant strains.
• Strain-sharing follows ecological principles, including strain dispersion and environmental/host filtering.
• Strain-sharing is dependent on the taxonomic identity of the strain shared, its capacity to adapt to a new environment and the characteristics of the ecosystem into which it is transferred.
• Microbiomes, especially if they are in a dysbiotic state, are also hubs for the emergence and spread of AMR genes.

Muhummed, A.M., Lanker, K.C., Yersin, S. et al. One Health, One Microbiome. Microbiome 13, 216 (2025). https://doi.org/10.1186/s40168-025-02231-6

Policies devised and implemented by the U.S. Health and Human Services (HHS) Secretary are ironically detrimental and diametrically counter to President Donald J. Trump’s “Make America Healthy Again (MAHA)”

U.S. President Donald  J. Trump and HHS Secretary Robert F. Kennedy, Jr. speaking with attendees at an Arizona for Trump rally at Desert Diamond Arena in Glendale, Arizona, Aug. 23, 2024

“Friday’s layoffs swept up scientists involved in responding to disease outbreaks and running an influential journal. Officials said the mistaken dismissals were being rescinded.”

“The CDC Mutual Aid Network provides direct emergency funds to fired CDC employees, fellows, and contractors facing financial hardship. Over 99 cents of every dollar goes straight to those in need.”

“… Lonsdorf is co-director of the Jane Goodall Institute’s Gombe Ecosystem Health Project, along with Thomas Gillespie, professor and chair of Emory College’s Department of Environmental Sciences. The pioneering project developed a “One Health” approach to quantify illness and methods of disease transmission between humans, wildlife and domestic animals at Gombe, to design effective interventions. …”

Gregory C. Gray, MD, MPH, FIDSA

Professor in Infectious Disease Epidemiology, Departments of Internal Medicine (Infectious Diseases), and Microbiology and Immunology.

University of Texas Medical Branch (UTMB)

301 University Boulevard, Route 0435

Galveston, Texas  77555-0435

Phone: (409) 772-0633

FAX: (409) 772-6527

www.utmb.edu/one-health

Email: gcgray@utmb.edu

ALSO SEE: https://podcasts.apple.com/us/podcast/episode-5-ft-dr-gregory-gray/id1825190127?i=1000729537174 and

https://substack.com/@canaryinacornfield/note/p-175030701?r=36ndv6&utm_source=notes-share-action&utm_medium=web 

Provided by Interviewer:

Adam Shriver, PhD

Director of Wellness and Nutrition

Harkin Institute for Public Policy

Check out our new podcast, Canary in a Cornfield!

Opinion

We took an oath to declare dangers when we found them. We’re doing that again today.

“Under the “One Health” initiative, the DLS is working with the Directorate General of Health Services (DGHS) to educate communities on proper …”

“What was even more shocking than a US President telling pregnant women, “Don’t take Tylenol [paracetamol, acetaminophen], don’t take it…fight like hell not to take it”, was watching the Director of the National Institutes of Health (NIH) stand approvingly by his side. The White House briefing on Sept 23 was a live seminar in health disinformation. Robert F Kennedy Jr, Secretary of the Department of Health and Human Services, accused NIH of creating a culture of “politicised science” and “corruption”. He described paracetamol use during pregnancy as having a “potential association” with adverse neurodevelopmental outcomes, such as autism and attention-deficit hyperactivity disorder (ADHD). He reported an “exciting therapy” for autism, based on no new evidence—leucovorin. And he then drifted into his obsession: vaccine safety. He alleged that previous administrations had gaslighted and marginalised mothers who believed their child had been injured by a vaccine. Jay Bhattacharya, NIH’s Director, blamed scientists for allowing taboos to block research that might give a “politically incorrect answer”. Marty Makary, Commissioner of the Food and Drug Administration, spoke of inaugurating an “historic shift in medical culture”. “We now have data we cannot ignore”, he said. He quoted the Dean of the Harvard T H Chan School of Public Health, Andrea A Baccarelli: “There is a causal relationship between prenatal acetaminophen use and neurodevelopmental disorders of ADHD and autism spectrum disorder.” …”