One Health Publications

“The One Health approach, an interdisciplinary strategy with focal point on human, animal, and environmental health interconnections, appears to be the right tool for researching asthma prevention and treatment”

Abstract: Asthma continues to be a disease for which there is no cure, even if it can be very well controlled with the appropriate therapies, which take into account the specific phenotype. The paradox of asthma is that asthma can heal spontaneously, albeit in a small percentage of cases. This observation is highly relevant, since understanding the mechanisms of spontaneous healing can pave the way for new strategies for treating asthma. It is likely that the lack of cure for asthma is due to the fact that current therapies target downstream mediators of the inflammatory response. Asthma can be considered a response of maladaptation of the airway epithelium to the environment, through the orientation of the innate immunity towards an inflammatory response. The important effect of the environment on asthma progress comes from interventions which help children who live in disadvantaged urban neighborhoods move to higher resourced neighborhoods. It is quite interesting that the magnitude of decrease of exacerbations associated with moving was larger than the effect of inhaled corticosteroids and similar to that observed for the effect of biologic agents. Alpine altitude climate treatment is a natural treatment that targets biological pathway, improving various outcomes such as asthma control and quality of life, exacerbation rate and hospitalizations. If as researchers we want to set ourselves the goal of achieving complete remission of asthma, without the need for ongoing maintenance treatment, we need to change the approach to finding new asthma treatment strategies. The One Health approach, an interdisciplinary strategy with focal point on human, animal, and environmental health interconnections, appears to be the right tool for researching asthma prevention and treatment.

“One Health is an approach that recognizes that the health of people is closely connected to the health of animals and the shared environment. Though …”

Advancing Health Care in Humans, Animals and the Environment

SEE One Health at UTMB Advancing Health in Humans, Animals and the Environment on Vimeo  (https://vimeo.com/834561067)

Provided to the One Health Initiative team/website by:

Brianna Kreditor, MPH

Research Associate II, Internal Med-Infectious Diseases

UTMB One Health Laboratory

Department of Internal Medicine (Infectious Diseases)

The University of Texas Medical Branch

301 University Blvd., Galveston, TX 77555-0435

E brkredit@utmb.edu

UTMB One Health

Abstract

The purpose of this manuscript, which is part of the Currents in One Health series, is to take a comparative approach to stem cell treatment for tendon injury and consider how the horse might inform treatment in other veterinary species and humans. There is increasing experimental and clinical evidence for the use of bone marrow–derived mesenchymal stem cells to treat tendon injuries in the horse. The same evidence does not currently exist for other species. This manuscript will review why the equine superficial digital flexor tendon core lesion might be considered optimal for stem cell delivery and stem cell interaction with the injury environment and will also introduce the concept of stem cell licensing for future evaluation. The companion Currents in One Health by Koch and Schnabel, AJVR, October 2023, addresses in detail what is known about stem cell licensing for the treatment of other diseases using rodent models and how this information can potentially be applied to tendon healing.

Our ancestor’s genes provided plague protection but may have also caused negative autoimmune system effects: What this may mean when a new virus strikes us in the future

“Could evolutionary genetics – the study of our genes over time – come to our aid in fighting future pandemics? We have been coping with widespread infectious diseases including HIV/AIDS, and a series of COVID pandemics – many of which have been tamed and cured. What is not known is how well we will cope with the next infectious disease threat and, as I recently argued, it’s time to get serious about preventing pandemics.  The extent to which our twenty-first-century systems will be able to effectively respond is still unknown. But new groundbreaking scientific efforts have been looking back and forward to gauge and enhance our capacity to deal with whatever comes next.  …”

The Event

It is a unique interdisciplinary platform that brings together professionals and experts in human health, animal health, environmental and plant health. With the participation of world-renowned speakers, both national and international, this event is emerging as a fundamental space for the exchange of knowledge and advances in the One Health and One Welfare approach.

The congress will have participants from various areas, such as medicine, nursing, bacteriology, biology, veterinary medicine, animal husbandry, environmental engineering, food engineering and many others. This wide variety of disciplines allows for a comprehensive approach to the interconnectedness of human, animal, environmental and plant health.

Prospective research endeavors should strive to enhance our comprehension of the natural reservoirs of monkeypox and its transmission dynamics, evaluate sustained immune responses to novel vaccines, and investigate the potential impact of One Health strategies.

“Abstract

Monkeypox, a viral zoonotic ailment originating in the Central and West African regions, has escalated into a global health issue of growing concern. The current analysis offers an exhaustive examination of monkeypox, emphasizing its historical progression, etiology, epidemiological patterns, pathophysiological mechanisms, clinical manifestations, diagnostic methodologies, treatment modalities, and preventive strategies. The worldwide discontinuation of smallpox vaccination has contributed to an increased incidence of monkeypox, driven by the expansion of vulnerable host populations. Significant strides in diagnostic procedures, prospective antiviral treatments, and vaccine development exhibit potential in managing this affliction, yet obstacles remain in terms of disease control, prevention, and treatment. Additionally, the international propagation of monkeypox underscores the need for robust public health initiatives and the significant role played by global health institutions in disease containment. Prospective research endeavors should strive to enhance our comprehension of the natural reservoirs of monkeypox and its transmission dynamics, evaluate sustained immune responses to novel vaccines, and investigate the potential impact of One Health strategies. This analysis underscores the pressing necessity for increased research and synchronized global efforts to tackle this emergent infectious malady.”

AVMA Journals – American Veterinary Medical Association

Abstract OBJECTIVE To examine the prevalence and context of one–health conversations between veterinarians and clients in companion animal …

“Introduction

One health focuses on the interrelationships between the health of humans, animals, and the environment.^{1 Mission Statement – One Health Initiative}

Mission Statement

Recognizing that human health (including mental health via the human-animal bond phenomenon), animal health, and ecosystem health are inextricably linked, One Health seeks to promote, improve, and defend the health and well-being of all species by enhancing cooperation and collaboration between physicians, veterinarians, other scientific health and environmental professionals and by promoting strengths in leadership and management to achieve these goals.

Vision Statement:
One Health (formerly called One Medicine) is dedicated to improving the lives of all species—human and animal—through the integration of human medicine, veterinary medicine, and environmental science.

One Health shall be achieved through:

1. Joint educational efforts between human medical, veterinary medical schools, and schools of public health and the environment;
2. Joint communication efforts in journals, at conferences, and via allied health networks;
3. Joint efforts in clinical care through the assessment, treatment, and prevention of cross-species disease transmission;
4. Joint cross-species disease surveillance and control efforts in public health;
5. Joint efforts in better understanding of cross-species disease transmission through comparative medicine and environmental research;
6. Joint efforts in the development and evaluation of new diagnostic methods, medicines and vaccines for the prevention and control of diseases across species and;
7. Joint efforts to inform and educate political leaders and the public sector through accurate media publications.  …”

The concept of one health dates back to at least the 1800s when the term “zoonosis” was introduced, linking human and animal diseases.² The one-health concept has been amplified in response to recent zoonotic disease outbreaks with public health implications (eg, COVID-19, H1N1 influenza, severe acute respiratory syndrome, Ebola, and Zika). Currently, the one-health approach is endorsed by major health organizations, such as the CDC, WHO, Food and Agriculture Organization of the United Nations, and World Organization for Animal Health^3,4. …”

“… Therefore, we recommend that the governments of the region support the One Health approach to reducing the risk of zoonotic disease transmission in their respective countries.”

“… Last, our capacities to manage invasive hematophagous arthropods in a sustainable way for worldwide ecosystems can be improved by promoting interactions among experts of the health sector, stakeholders in environmental issues and policymakers (e.g. the One Health approach) while considering wider social perceptions. …”

“ … Penn State students, along with students from Taiwan, Grenada, Nepal, Ecuador, Brazil, China and Bahrain, completed the summer program. Through their studies, they had the opportunity to gain insight on global health topics, including social determinants of health, disease prevention, medical-legal issues, One Health and emergency preparedness. …”

Official Journal of The World Medical Association, Inc. Nr. 2, June 2023, Vol. 69

Repeat: ‘One Medicine−One Health’: An Historic Perspective by One Health Initiative team, June 2023 Pages 18 -27.

International Journal of One Health  –  RESEARCH ARTICLE Open Access

Abstract Background: Elephants are exploited for public entertainment tourism throughout Asia and Africa. Areas of concern include public health and safety and animal welfare.

Materials and Methods: We examined over 500 scientific publications with respect to our primary objectives, as well as non-peer-reviewed materials relating to other relevant subject matters (e.g., tourism promotional websites and YouTube films) for background purposes, although these additional materials were not included in this review. Results: We identified at least 12 confirmed or potential zoonotic and other transmissible infections relevant to the elephant tourism sector, and at least 13 areas of animal welfare concern.

Conclusion: Infection and injury risks between humans and captive elephants cannot be safely controlled where close contact experiences are involved, arguably creating an unredeemable and indefensible public health and safety situation. Elephant welfare within some sectors of the close contact interactive tourism industry continues to involve significant mistreatment and abuse. To alleviate key One Health concerns outlined in this study, we recommend several types of regulation, monitoring, and control regarding interactions at the human-captive elephant interface. These include legal bans on the promotion and performance of close contact experiences, combined with strong enforcement protocols; new policies toward discouraging elephant tourism; 24/7 surveillance of captive elephants; and the adoption of independent scientific positive list systems for tourism promoters or providers regarding public observation of free-ranging elephants within national parks and protected areas.

Brucellosis One Health actors include Public Health and Veterinary Services, microbiologists, medical and veterinary practitioners and breeders.

Aug 11, 2023

“… Furthermore, the emphasis on the concept of ‘One Health’ at a global level recognizes the interconnectedness of people, animals, plants, and the environment, advocating a collaborative, multi-sectoral and transdisciplinary approach, urging the creation of resilient systems at the national level. However, there are differences among the nations in their programs and the investments to support disease prevention and control, and that is a matter of concern especially in the low- and middle-income countries, where higher population pressure negatively impacts the healthcare delivery and medical hygiene standards caused by secondary infections. …”