Long COVID pandemic in the aftermath of the acute phase

Faculty of Medicine

“How are studies on pandemics or One-health related to your field of research? … So, I think it is pertinent for the One–Health initiative to be interested in these long-term effects as well. …”

“ … How are studies on pandemics or One-health related to your field of research?

I believe these late effects are important in pandemic research. Long COVID has shown that we need to be interested in the acute situation, which is major with all the countermeasures and the lockdowns. At the same time, it is important to be interested in the chronic sequels afterwards. What we are seeing now eventually is a kind of long COVID pandemic in the aftermath of the acute pandemic, which of course is also part of the greater picture. So, I think it is pertinent for the One-Health initiative to be interested in these long-term effects as well. By this,I mean that in addition to being interested in the biological mechanisms pertaining to the infection and immunity, we should also be interested in, for instance, the mental, psychological and social phenomena that occur simultaneously.

In the study we published, we found that in the group that did not have COVID, there was also a large number of people with chronic fatigue and other chronic problems. We believe this was partly due to the more general pandemic effect on society. The anxiety related to the situation, the lockdowns, and the social isolation people experienced. All this has consequences for symptoms. This is therefore very complex and very interesting also from a societal perspective.

How would you describe a research in three words?

With three words it is multidisciplinary, it is rooted in the clinical world as partly observational and partly clinical trials. I hope it is of high quality and that it is something that will contribute to the understanding of this phenomenon.  …”

External Learning Resources in Education

SEE: https://www.med.uio.no/she/english/studies/learning-tools/

One Health

The One Health approach is necessary to effectively prevent, detect and respond to health challenges that arise at the interface between humans, animals and the environment. 

One Health Course Series

Human and Animal Health Course

Competency Framework

JGPOH

Journal of Global, Public and One Health

Eliudi S. Eliakimu, MD, MPH et. al., Principal Medical Officer, Health Services Inspectorate & QA Section, under QA Division, MoHSW.

Tanzania 

Article [https://jgpoh.com/archives/28087]

Conclusion

Antimicrobial resistance is a test of our collective ability to tackle interconnected and complex challenges. A One Health approach provides a comprehensive framework for addressing AMR but demands bold leadership, enforceable commitments, and steadfast collaboration among governments, industries, and civil society. With the right actions, AMR can be curbed, protecting lives, ecosystems, and economies for generations to come.

SEE: The urgent need for a One Health approach – EPHA

” …  “This report highlights the interrelatedness of antimicrobial resistance and antibiotic use in human, animal, plant and environmental sectors—the One Health concept,” said Sophie E. Katz, MD, an assistant professor of pediatric infectious diseases at Vanderbilt University Medical Center, in Nashville, Tenn. “It is meant to raise awareness for pediatric primary care providers, and also to showcase that while we have made significant improvements in antibiotic use in agriculture since the last report was published, there are still improvements to be made.”

Antimicrobial resistant bacteria cause at least 2.8 million annual infections and more than 35,000 deaths, including in children, according to the CDC. The misuse and overuse of antibiotics in human and animal medicine is a significant contributor to the emergence and spread of resistant pathogens, the authors of the report wrote.

Addressing these issues will require dedicated efforts and a focus on the tenets of a One Health approach. “I very much hope that these concerns are addressed via legislation and/or public health efforts,” Dr. Katz told Infectious Disease Special Edition.  …”

Study enrolls dogs with urothelial carcinoma to assess anti-cPD-L1 monoclonal antibody (mAb) safety and efficacy, with potential applications for human treatments.

“Pitt’s first observance of One Health Day, an international, transdisciplinary forum on global health, featured a presentation by William T. Mallon, senior director of strategy and innovation development at the Association of American Medical Colleges (AAMC), who serves as the point person for sustainability and climate action.

John de Jong, DVM, President, World Veterinary Association

‘Subscribe to the WVA Newsletter here: http://eepurl.com/iiS2IT‘

Provided by:

Magda Lourenço

Executive Manager at

World Veterinary Association: Home

One Health Newsletter Vol 16 Issue 1

To subscribe use link below:

https://share.hsforms.com/1fMe0UkgFSya0_OGmpjNNAQdc7v9?__hstc=164153568.f7bb43be9501ead8981c3db2b826a837.1702398504269.1731894700037.1732048269305.284&__hssc=164153568.4.1732048269305&__hsfp=2142369586

OneHealthdrugs

Designed initially to celebrate the European Researcher night (27 September 2024), we wanted to extend our communication through the period after that day, because we cannot forget our mission as a Researchers. This communication represents a Joint message for the European Researcher right from One Health Initiative (OHI) and COST Action OneHealthdrugs . 27 September 2024. We take the opportunity to focus this year on the Missing Professional in the Chemistry of Care: Medicinal Chemists and the One Health Philosophy The concept of One Medicine focused on the interconnection between animal health and human health with the inclusion of the connection with ecosystem health, bringing the One Health term into being. However, another key player is key to elevating this transdisciplinary approach—the Medicinal chemist. The environmental impact of medical waste derived from antivirals, antiparasitcs and antifungals, amongst others, is a key threat to human and animal health. Importantly, developing antimicrobial-resistant pathogens is a key public health concern compounding the effects of human and animal contact with medical waste in effluent systems and other water sources. The skills required in designing compounds using the principles of green chemistry and implementing antimicrobial stewardship are tools of the chemist that can be used for educating and preparing future medical and veterinary graduates for a more eco-friendly approach to practice. These concepts are represented in our video.

U.S. Centers for Disease Control and Prevention:

(CDC) A(H5N1) Bird Flu Response Update November 18, 2024 | Bird Flu | CDC

At a glance 

CDC provides an update on its response activities related to the multistate outbreak of avian influenza A(H5N1) virus, or “H5N1 bird flu,” in dairy cows and other animals in the United States. 

Environmental public health research at the U.S. Environmental Protection Agency: A blueprint for exposure science in a connected world

Journal of Exposure Science & Environmental Epidemiology (2024) Cite this article

Abstract

Exposure science plays an essential role in the U.S. Environmental Protection Agency’s (U.S. EPA) mission to protect human health and the environment. The U.S. EPA’s Center for Public Health and Environmental Assessment (CPHEA) within the Office of Research and Development (ORD) provides the exposure science needed to characterize the multifaceted relationships between people and their surroundings in support of national, regional, local and individual-level actions. Furthermore, exposure science research must position its enterprise to tackle the most pressing public health challenges in an ever-changing environment. These challenges include understanding and confronting complex human disease etiologies, disparities in the social environment, and system-level changes in the physical environment. Solutions will sustainably balance and optimize the health of people, animals, and ecosystems. Our objectives for this paper are to review the role of CPHEA exposure science research in various recent decision-making contexts, to present current challenges facing U.S. EPA and the larger exposure science field, and to provide illustrative case examples where CPHEA exposure science is demonstrating the latest methodologies at the intersection of these two motivations. This blueprint provides a foundation for applying exposomic tools and approaches to holistically understand real-world exposures so optimal environmental public health protective actions can be realized within the broader context of a One Health framework.

Conclusion

Within the context of the One Health framework, we will demonstrate how genomic technologies can be utilised to improve the overall quality of life for half the world’s population.