One Health Publications

Originally published in EDI Journal 1/2019 European Journal for Dental Implantologists www.teamwork-media.de/project/edi-journal Implementation of One Health in undergraduate education Working together from curricula to practice One Health is a concept that recognises interlinks between human health, animal health and the environment. The value of the One Health holistic approach is undisputed when it comes to tackling different challenges to public and animal health. Academics, students, professionals and policy makers were engaged in lively discussions about One Health in Paris on 5 December 2018. Participants exchanged their views about the value and necessity for working together on a common understanding of the One Health concept and on promoting interdisciplinary collaboration starting from universities. The European associations representing medical doctors, dentists, veterinarians and their students – among the Council of European Dentists – remain committed partners for future actions to be undertaken towards the implementation of the One Health approach in education and practice and call on academics and policy makers at national and European level: • to work on the development of a clear definition to ensure a common understanding of the One Health concept; • to foster exchanges between medical, dental and veterinary schools under the One Health approach; • to work together on One Health Competences; • to support and ensure the continuation of this open debate; • to support the further investigation of implementation of One Health interdisciplinary education of doctors, dentists and veterinarians. Source: Council of European Dentists (CED) Please see attached PDF for full article. Permission to post on One Health Initiative website granted March 19, 2019 by: Isabel Lamberty ∙ Redaktion | Editor EDI Journal teamwork media GmbH ∙ Hauptstr. 1 ∙ 86925 Fuchstal ∙ Germany Fon +49 8243 9692-32 ∙ Fax +49 8243 9692-22 ∙ i.lamberty@teamwork-media.de www.teamwork-media.de ∙ www.teamwork-campus.de ∙ www.dental-bookshop.com ∙ pi.dental-online-channel.com Geschäftsführer/Managing Director Uwe Gösling Sitz der Gesellschaft Fuchstal | Amtsgericht Augsburg HRB 14984            

An old but a good video... video.ku.dk One Health by Professor Liza Rosenbaum Nielsen An approach to solve global health challenges

The Collaboration Between Human and Animal Medicine Written by Carol Petersen, RPh CNP – Pet Health Pharmacy - Feb 28, 2019     The idea of a “One Health” organization started with the AVMA, the American Veterinary Medical Association, back in 2006 who called together a multi-discipline task force to further develop the idea. They called together representatives from many health professions to discuss the possibilities of blending and collaborating information, solutions and treatments in order to improve animal and human health and the environment. The information and ideas and final presentation they gathered can be found at www.onehealthinitiative.com. The “One Health” movement calls for active collaboration between the professionals caring for animals and the professionals caring for humans. ... Read complete article at https://www.pethealthpharmacy.com/one-health-initiative/

Journal                                                         Medical Teacher Latest Articles Letter to the Editor Incorporating the One Health framework in medical education Helena J. Chapman Science & Technology Policy Fellow, American Association for the Advancement of Science at NASA Applied Sciences Program, Washington, D.C., USACorrespondencehjchapman@gmail.com & Shobhana Gupta Open Innovation and Community Applications Manager with Arctic Slope Technical Services at NASA Applied Sciences Program, Washington, D.C., USA Citation: Helena J. Chapman & Shobhana Gupta (2019) Incorporating the One Health framework in medical education, Medical Teacher, DOI: 10.1080/0142159X.2018.1554897 Published online: 08 Feb 2019 Dear Sir Health impacts of environmental exposures, such as poor air quality and emerging and reemerging infectious diseases, contribute to an estimated 25% of the global disease burden. As physician-scientists, we stress that medical education programs should incorporate key One Health competency domains, connecting human, animal, and environmental health (Frankson et al. 2016 Frankson R, Hueston W, Christian K, Olson D, Lee M, Valeri L, Hyatt R, Annelli J, Rubin C. 2016. One Health core competency domains. Front Public Health. 4:192.[Crossref], [PubMed], [Web of Science ®], , [Google Scholar]), into didactic coursework and clinical training, preparing the future workforce to respond appropriately to global health challenges. ... To read in full, please see https://www.tandfonline.com/doi/full/10.1080/0142159X.2018.1554897?scroll=top&needAccess=true. Permission granted March 11, 2019 to One Health Initiative website to post Free-to-View at https://www.tandfonline.com/doi/full/10.1080/0142159X.2018.1554897?scroll=top&needAccess=true, courtesy of: Niall Rundle, Managing Editor, Medicine & Health Taylor & Francis – Journals, 4 Park SquareMilton Park Abingdon OX14 4RN UK Taylor & Francis Group is a trading name of Informa UK Limited, registered in England under no. 1072954 Note: Dr. Chapman [MD, MPH, PhD] is a physician member of the One Health Initiative team’s Advisory Board http://www.onehealthinitiative.com/advBoard.php.

  One Health Happenings! - March 11, 2019 See https://conta.cc/2EQyRtZ

The Lancet Planetary Health Volume 3, Issue 2, February 2019, Pages e64-e65 open access Comment Collaboration between human and veterinary medicine as a tool to solve public health problems https://doi.org/10.1016/S2542-5196(18)30250-X “The implementation of an effective collaboration between human and veterinary medicine, environmental protection, and public health is not a fully achieved goal, although several examples of integrated approaches have been documented in Europe. The concept of one world, one health has recently appeared, indicating that the world has suddenly woken up to the link between animal diseases, public health, and the environment. The need for collaboration between the human, animal, and environmental health sectors is due to the increase in emerging human infectious diseases with a zoonotic origin and in the resistance of microorganisms to antimicrobial drugs.1 The main fields in which this new concept of collaboration has been applied are zoonosis and zooprophylaxis, vaccines, and antibiotic resistance, via the establishment of networks of professionals in the One Health area. The historical background of One Health laid the foundations for the realisation of concrete interventions or future perspectives of collaboration between human, veterinarian, and environmental institutions. …”

  Romanian EU Presidency aims to strengthen Europes One Health approach to fighting ... World Health Organization Antimicrobial resistance (AMR) is widely recognized as one of the 21st centurys greatest threats to health, welfare and food security. Worldwide, an ... http://www.euro.who.int/en/countries/romania/news/news/2019/3/romanian-eu-presidency-aims-to-strengthen-europes-one-health-approach-to-fighting-antimicrobial-resistance  

  1.2 Million Grant for One Health approach to study bacteria behind diarrheal disease Quadram Institute $1.2 Million Grant for One Health approach to study bacteria behind ... led by the Milken Institute School of Public Health (Milken Institute SPH) at the ... https://quadram.ac.uk/1-2-million-grant-for-one-health-approach-to-study-bacteria-behind-diarrheal-disease/  

  One Health conference draws experts to Thailand Environmental Factor Newsletter Participants in the International Conference on One Medicine One Science explored the intersection of human, animal, and environmental health. https://factor.niehs.nih.gov/2019/3/science-highlights/one-health/index.htm  

  DUKE (USA) One Health Team News -  ISSUE 12 March 2019 SEE COMPLETE ISSUE: https://mailchi.mp/cd1336e3711c/march-issue

Global One Health Initiative – Ohio State University https://globalonehealth.osu.edu/  

One Health Model Key for Human and Animal Health Lancaster Farming Public health, veterinary and environmental experts alike recognize the need to use a One Health approach to try to solve or slow the spread of this ...

The Mandate for a Global “One Health” Approach to Antimicrobial Resistance Surveillance Siddhartha Thakur1, **Gregory C. Gray2 Affiliations: 1 College of Veterinary Medicine, NC State, Raleigh, North Carolina; 2 Division of Infectious Diseases, Duke Medicine, Global Health Institute, and Nicholas School of the Environment, Duke University, Durham, North Carolina *Address correspondence to Siddhartha Thakur, College of Veterinary Medicine, NC State, 1060 William Moore Dr., Raleigh, NC 27606. E-mail: sthakur@ncsu.edu   Authors’ addresses: Siddhartha Thakur, College of Veterinary Medicine, NC State, Raleigh, NC, E-mail: sthakur@ncsu.edu. Gregory C. Gray, Division of Infectious Diseases, Duke Medicine, Global Health Institute, and Nicholas School of the Environment, Duke University, Durham, NC, E-mail: gregory.gray@duke.edu. Publisher: The American Society of Tropical Medicine and Hygiene Source: The American Journal of Tropical Medicine and Hygiene, Volume 100, Issue 2, Feb 2019, p. 227 - 228 DOI: https://doi.org/10.4269/ajtmh.18-0973 or https://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0973 In 1940, one year before the first administration of penicillin in man, two members of the team who discovered the drug revealed that resistance to penicillin already existed.1 Since then, as antimicrobial resistance (AMR) has progressed in the wake of exponential antimicrobial use, scientists have raced against extraordinarily efficient microbial gene dissemination and evolution to provide effective antimicrobial therapeutics. Today, with the existence of genes resistant to every natural and synthetic antimicrobial compound, national surveillance systems track AMR in human and animal populations to deepen our understanding of resistance and find ways to circumvent it. Although we have established surveillance systems across North America and Europe, pathogens do not respect international boundaries, and the emergence of resistance in any country poses a worldwide threat. In this issue of the AJTMH, Hedman et al.2 report spillover of AMR to developing world settings with no prior history of agricultural antimicrobial use. We are reminded that surveillance must become a global “One Health” effort if we are to solve one of today’s most significant threats to human, animal, and environmental health. Antimicrobial resistance has reached its tipping point, and some are saying we are now in the post-antibiotic era. Recent reports have highlighted this trend, including the emergence of multiple plasmid-mediated colistin resistance genes in human and animal pathogens,3 spread of metallo-beta-lactamase-1 in India,4 and the emergence of plasmid-mediated carbapenem-resistant Enterobacteriaceae in swine for the first time in the United States.5 Leading world health agencies consider the threat of AMR as paramount and recognize its complex causation: expanding human and domestic animal populations; increased globalization, international trade, and demand for animal source foods; and all-too-easy access to antimicrobials in both developed and developing countries. The proficiency of genome evolution via horizontal gene transfer and the emergence of new forms of resistance have compounded the lack of new antibiotic discovery and development, while intensifying the threat posed by drug-resistant pathogens. By 2050, an estimated 10 million human lives per year will be at risk if we fail to attenuate the rise of drug resistance, and critical medical procedures such as administration of cancer chemotherapy, joint replacement, and gastrointestinal surgery may be associated with increasing morbidity.6 The increase in AMR burden correlates with a 65% increase in antimicrobial consumption in humans between 2000 and 2015 in 76 countries7 and administration of 63,000 tons in animals in 2010, with a projected 67% increase in consumption by 2030.8 Antimicrobial resistance poses a particularly significant threat to low- and middle-income countries. This is due not only to the health-care challenges these countries face, but also to an increase in small-scale intensive animal production, exacerbated by poor sanitation infrastructure. The findings reported by Hedman et al. in this issue exemplify this problem and the difficulty of understanding the complicated dynamics of AMR transmission between humans and animals sharing the same environment. The researchers investigated the prevalence of CTX-M extended-spectrum beta-lactamases in chickens from small-scale poultry farms and in children living on the farms in rural Ecuador. CTX-M-mediated cephalosporin resistance was seen in bacteria both in commercially bred “broiler” chickens treated with high levels of antibiotics and in free-grazing animals that had no direct exposure to antibiotics. Resistance was also detected in bacteria from children in the community. After phylogenetic analysis, the authors reported a shared evolutionary history between chicken and human samples. Hedman et al., thus, provide valuable insight into the rise of phenotypic resistance and avian-to-human spillover in areas that have previously reported low AMR levels in both poultry and humans. Altogether, the data provided by Hedman et al. support a familiar narrative: gene exchange is a property of bacteria that efficiently enables the transmission of resistance between animals and humans. Of particular importance to surveillance systems, the study also highlights the pivotal role of the environment in AMR transmission. The ability of the environment to act as a reservoir for resistance is not a new concept and may have promoted the potential spillover event described by Hedman et al. in Ecuador. Indeed, the environmental AMR resistome consists of more than one million distinct bacterial species, which markedly exceeds the number of species that infect human and animal populations.9 Despite the knowledge of environmental influences on AMR, current surveillance systems often neglect environmental sampling. It is now crucial that we re-emphasize the role that the environment plays as a reservoir and in maintaining AMR genes as we establish surveillance systems to combat AMR. We know that many of the resistance mechanisms we see in veterinary clinics and animal production systems likely have environmental origins. Recently, we have reported horizontal dissemination of resistance determinants in multiple Salmonella serotypes across commercial swine farms following manure application.10 In addition, numerous studies have reported very little difference in the shedding of drug-resistant bacterial strains between animals raised under organic or antimicrobial-free production systems.11–14 Combined with studies such as that conducted by Hedman et al., these findings demonstrate the need to apply a One Health approach and study environmental reservoirs more closely, rather than focusing only on the resistance that arises following antimicrobial administration.15–18 Importantly, combating AMR will also require global cooperation because decreasing the use of antimicrobials only in one population or in one country will not necessarily attenuate the spread of resistant strains. Collignon et al. conducted a multivariate analysis based on antimicrobial consumption data from 63 countries to determine the role of anthropological and socioeconomic factors in the global spread of AMR.19 At the country level, the authors suggested that improving sanitation, ensuring good governance, better access to clean water, increasing expenditure on improving public health care, and better regulation of the private health sector were all required for reducing AMR. Factors including poor sanitation, warmer temperatures, and higher corruption levels were consistently associated with a higher prevalence of AMR strains. Without harmonizing surveillance between nations, we will never know the extent of the AMR challenge, nor will we be able to combat it effectively. We are already taking strides to ameliorate this problem. In 2015, the World Health Organization launched the Global AMR Surveillance System (GLASS) to establish a standardized GLASS. So far, 40 countries are participating,20 and by collecting and analyzing AMR, epidemiological, clinical, and population-based data from these countries, systems such as GLASS can generate actionable data, improve analysis, influence policy decisions, and ultimately reduce the burden of AMR worldwide. **Dr. Gray is a member of the One Health Initiative team’s Advisory Board  http://www.onehealthinitiative.com/advBoard.php. REFERENCES Go to section...

UKRI One Health AMR research priorities showcased in Parliament Cambridge Network The UKRI Cross-Council AMR Initiative and Stephen Metcalfe MP, Chair of the Parliamentary and Scientific Committee and member of the Science ...

One Health Happenings! - February 13, 2019 https://conta.cc/2DwbvZQ

Advancing Legislation on ‘One Health’ in the United States of America One Health Newsletter, Volume 11, Issue 1, January 2019, ‘Advancing Legislation on ‘One Health’ in the United States of America’ (http://www.vet.k-state.edu/OneHealth/Vol11-Iss1/advancing_legislation.html) 

“One Health network for the prevention of vector-borne diseases around the Mediterranean and Black Sea regions” Supports One Health concept... https://www.medilabsecure.com/public.aspx?page=one_health_initiative

Kansas State University Manhattan, KS 66506 (USA) College of Veterinary Medicine   One Health Newsletter “The One Health Newsletter is a collaborative effort by a diverse group of scientists and health professionals committed to promoting One Health. This newsletter was created to lend support to the One Health Initiative and is dedicated to enhancing the integration of animal, human, and environmental health for the benefit of all by demonstrating One Health in practice. The theme of this issue is One Health Regulation and Policy. All of the articles below display exciting applications of the One Health concept. This issue of the One Health Newsletter was written by professionals, post doctoral associates, and graduate/veterinary students with the assistance of our faculty editorial board and guest contributors. ...” Please see http://www.vet.k-state.edu/OneHealth/Vol11-Iss1/index.html

  ISSUE 11 February 2019                      SEE COMPLETE ISSUE:   https://mailchi.mp/60a12617339e/february-issue     Recent Publications   The Mandate for a Global One Health Approach toAntimicrobial Resistance Surveillance In January 2019, Dr. Siddhartha Thakur of North Carolina State’s College of Veterinary Medicine drafted an editorial highlighting the importance of a One Health approach in reducing the burden of antimicrobial resistance (AMR). The editorial, published in the American Journal of Tropical Medicine and Hygiene, gave examples of how complex factors at the human, animal and environmental interface all contribute to the spread of AMR, a threat which is not contained by social or geographical boundaries. Dr. Thakur argues that surveillance for AMR in our increasingly globalized world must be a harmonized international effort.      Read more  

Pandemic Response Box launched by MMV and DNDi by Press Release - January 29, 2019 “...The Pandemic Response Box is one of several MMV and DNDi open science projects, which encourage collaboration and transparency in drug development research. MMV and DNDican provide advice, support and additional compound quantities to help researchers follow up on interesting findings.”  [calling this a “One Health” approach would be fitting]  http://outbreaknewstoday.com/pandemic-response-box-launched-mmv-dndi-61445/?fbclid=IwAR2MsjLGhDxC2S0zQSs5vaeExznygF8zU6yIwr8gzqcaDUf5x7Fq5JwDO1E