One Health Publications

CAPT Brianna Skinner, DVM, MPH, DACLAM
Senior Regulatory Veterinarian
Office of Counterterrorism and Emerging Threats (OCET)
Food & Drug Administration (FDA)

Annamaria Castiglia, DVM
One Health Coordinator
Center of Veterinary Medicine (CVM)
Food and Drug Administration (FDA)

CAPT Brianna Skinner is a Commissioned Corps Officer in the U.S. Public Health Service currently assigned to the Office of Counterterrorism and Emerging Threats (OCET) at the U.S. Food and Drug Administration (FDA) as a Senior Regulatory Veterinarian.  She serves as a co-lead for the operations of FDA’s One Health Steering Committee, as senior staff advisor for FDA’s Animal Welfare Council and as an animal model expert for the administration of policies to facilitate the availability of safe and effective medical countermeasures in OCET. Prior to transferring to the FDA, she worked at the Centers for Disease Control and Prevention leading clinical operations within the vivarium and consulting with principal investigators on animal care and use with infectious disease research. She earned her Doctor of Veterinary Medicine degree from Tuskegee University, her Master’s in Public Health from Benedictine University, and is board certified in laboratory animal medicine with the American College of Laboratory Animal Medicine.

Dr. Annamaria Castiglia is a Veterinary Medical Officer currently working for the Center of Veterinary Medicine (CVM) in the Office of the Director as the CVM One Health Coordinator. Prior to her position at FDA, she worked in Small Animal Practice and the Animal Health Industry both domestically and internationally. In 1999, she was relocated by Hoffman La Roche-Animal Health to Washington, D.C. to represent them on Capitol Hill. During that year she completed her Lobbying Training Programs in Washington, D.C. In 2005-2019, she joined the One Health Academy as the coordinator in Washington, D.C. and was a member of the One Health Academy Board of Directors. She earned her Doctor of Veterinary Medicine degree from Bologna University, in Bologna Italy. She also completed the following post graduate programs: small animal medicine at the Animal Medical Center, New York City, New York; food animal medicine at the University of Pennsylvania Veterinary College, and swine health and management at Michigan State University and Iowa State University.

About the Presentation

The One Health concept works at the interconnection of three domains:  human, animal, and environmental health. One Health presents a more holistic view of the U.S. Food and Drug Administration’s (FDA) mission. The FDA’s efforts to improve health go beyond recognizing disease transmission through an isolated lens of human health and acknowledge human-animal interactions and associated environmental factors. The One Health concept’s convergence already exists in the FDA’s mission statement when considering the Agency’s responsibilities and authorities. The Agency fulfills its mission to benefit both people and animals by ensuring the safety and efficacy of regulated products such as food or feed, drugs, devices, and human biologics. It regulates the manufacturing, marketing, and distribution of regulated products to ensure that safety and quality standards are met that benefit both people and animals. The Agency utilizes a multidisciplinary and multisectoral approach to gathering data that enhances more informed, evidence-based regulatory decisions when establishing standards and guidance. Last but not least, FDA coordinates regulatory pathway measures fostering the advancement of medical countermeasures that diagnose, prevent, protect, and treat conditions derived from intentional or unintentional emerging threats for chemical, biological, radiological, or nuclear materials. These threats hold no boundaries and can adversely impact people and animals alike. This presentation will describe the One Health concept and how it applies to FDA’s regulatory mission. It will also explain FDA’s application of the One Health concept in its regulatory activities.

Learning Objectives

1. Describe the One Health concept.
2. Examine how FDA applies the One Health concept in its activities.
3. Explain how FDA’s application of the One Health concept has national and international reach.
4. Discuss some One Health challenges.
5. Explore what the future may look like as FDA adopts a One Health approach.

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One Health

Various wild mammals have been identified as susceptible to monkeypox virus in areas that have long experienced monkeypox. These include rope squirrels, tree squirrels, Gambian pouched rats, dormice, non-human primates, among others. Some species may have asymptomatic infection. Other species, such as monkeys and great apes, show skin rashes typical of those found in humans. Thus far, there is no documented evidence of domestic animals or livestock being affected by monkeypox virus. There is also no documented evidence of human-to-animal transmission of monkeypox. However, there remains a hypothetical risk of human-to-animal transmission; as such appropriate measures such as physical distancing of persons with monkeypox from domestic pets, proper waste management to prevent the disease from being transmitted from infected humans to susceptible animals at home (including pets), in zoos and wildlife reserves, and to peri-domestic animals, especially rodents.

As future pandemics are likely to emerge from the coronavirus family of viruses and other zoonotic pathogens, an integrated approach to develop vaccines for zoonotic diseases is essential for success

June 18, 2022

by Craig Carter, DVM, PhD, Thomas Monath, MD and Rohini Roopnarine

in Health, Society

“ …  Broadening the field of One Health

Ramirez has watched—and helped shape—changes in how the field of One Health works.

Now, there’s less “helicopter research,” with scientists dropping in to conduct field studies and never reporting back to the community with the findings, she said.

Instead, “we’re doing a lot of capacity-building where we’re helping young scientists increase their abilities to address emerging needs and interviewing indigenous knowledge-keepers and scientists to learn how they approach One Health,” she said.

Her next project: Seeking larger, more sustainable funding sources to continue to grow COHR and the One Health Clinic in response to demand.

In a way, the COVID-19 pandemic is helping her make the case. “Now, everybody knows what zoonotic disease is, and there’s a lot of interest in emerging infectious diseases. I’m hoping that will bring more funders to this research,” she said.”

“In this study, our findings firstly demonstrate that P. yoelii 17XNL infection had significant anti-colon cancer effects in mice by inhibiting tumor cell proliferation and promoting mitochondrial apoptosis, which may relate to the inhibition of mitochondrial biogenesis and mitophagy. The results presented here may inspire a new approach for the treatment of colon cancer.”

“… “The challenge is to take an integrated and unified approach to these problems right through from agriculture and the environment to food production and human health, in what’s termed a One Health approach. To do that we need to collaborate with food and other associated industries to share research and innovation and deliver training activities.” …”

Offline: Why science is not enough – The Lancet

““Listen to the science.” The distinguished climate scientist, Thomas Stocker, was speaking at the Science7 Dialogue Forum in Berlin, Germany, on May 31, 2022. The occasion was the publication of statements from the science academies of G7 nations on antiviral drugs for pandemic preparedness, decarbonisation, oceans and the cryosphere, and One Health. …”

“… Local leaders hold the power to translate global promises into transformative changes

“We cannot protect human health without considering the impact of human activities that disrupt ecosystems, encroach on habitats, and further drive climate change”, had said Dr Tedros Adhanom Ghebreyesus, Director General of the World Health Organization (WHO) earlier this year. He had added that, “…to keep people safe, One Health must be translated into local-level systems.”

That is why local leaders from around 80 cities of over a dozen countries in Asia and the Pacific had endorsed a Declaration rooted in One Health approach, at the 6th Asia Pacific Summit of Mayors (6th APCAT Summit) in December 2021, said Professor Tjandra Yoga Aditama, former Director General (Disease Control), Ministry of Health, Indonesia, and former Director (communicable disease control), of the WHO for South-East Asia region.

Dr Andre Furco added: “We cannot anymore work in silos, as these diseases are at the interface of human health, animal health and environment. So we need to work together to be able to better respond to them. One Health approach must be applied at the local level with a whole-of-society approach.” …”

“… We have to treat our environment and our natural resources with respect and care. The pandemic has taught us that animal to human spillover [of pathogens] is possible and that it can cause devastation that is unprecedented.

India is now working towards setting up a One Health Centre in Nagpur, which should be ready in about two years time. This centre is primarily focused on a holistic approach towards detecting infections, where veterinary and medical scientists will work alongside each other to understand, anticipate and, in the long run, prevent zoonotic spillovers.

One Health is an approach calling for the collaborative efforts of multiple disciplines working locally, nationally and globally, to attain optimal health for people, animals, and our environment. …”

 In this session, experts from civil society and multilaterals will discuss why robust animal health systems are critical to putting One Health into practice and reduce the risk of zoonoses spilling over to people.

June 28, 2022

Over 15 million dead from COVID-19 and output losses close to $14 trillion,  but we need all hands on deck to deal with this and future pandemics

by Richard Seifman, JD, MBA

June 2, 2022

“ … The project aims at elevating the role of the humanities, particularly English and rhetorical studies, within the One Health initiative. One Health is a multi-disciplinary approach that works on all levels from local to global to attain optimal well-being for people and society, the environment, plants and animals. The grant intends to broadly and intentionally infuse the humanities into the initiative by creating a new minor titled One Health Communications, which hopes to bridge the study of writing and rhetoric with pre-veterinary, pre-health, and science programs; provide professional development workshops for DelVal faculty focused on integrating lessons from the field of Rhetoric into science programs; and bring speakers to campus for the university’s One Health series and Business and Humanities Colloquia. …”

Provided by:

A generalizable one health framework for the control of zoonotic diseases | Scientific Reports (nature.com)

A new publication is available that outlines a Generalizable One Health Framework for using a One Health approach within zoonotic disease programs at the local, sub-national, national, regional, or international level. The framework includes five specific steps and corresponding activities to help users develop capacity to coordinate zoonotic disease programs across sectors and is applicable to common zoonotic diseases in most settings.

Effectively preventing and controlling zoonotic diseases requires a One Health approach that involves collaboration across human health, animal health, and environmental sectors, as well as other partners. This framework provides a structure for using a One Health approach in zoonotic disease programs and can help build capacity for preventing and controlling zoonotic diseases at the local, sub-national, national, regional, or international level.

Provided by:

Laura (Smith) Murrell, MA (she/her)

Communication Lead, One Health Office

Health Communication Specialist, Health Communication Science Office

National Center for Emerging and Zoonotic Infectious Diseases

Centers for Disease Control and Prevention

(O) 404-639-7704

(M) 470-572-3178

A Generalizable One Health Framework for the Control of Zoonotic Diseases

Coupled with recommendations for implementing a One Health approach for zoonotic disease prevention and control in technical domains including laboratory, surveillance, preparedness and response, this framework can mobilize One Health and thereby enhance and guide capacity building to combat zoonotic disease threats at the human–animal–environment interface. Scientific Reports